The neurotoxicity of β-N-oxalyl-l-αβ-diaminopropionic acid, the neurotoxin from the pulse Lathyrus sativus
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چکیده
منابع مشابه
A Novel Potentiometric Sensor for Determination of Neurotoxin β-N-Oxalyl-L-α, β-Diaminopropionic Acid
A novel potentiometric sensor based on ionophore (Cd(NH2CH2CH2OCH2CH2OCH2CH2NH2)Ag3(CN)5) for the determination of β-N-oxalyl-L-α, β-diaminopropionic acid (ODAP) is developed. The ODAP-selective membrane sensor demonstrates high sensitivity and short response time. The detection limit of the ODAP-selective membrane sensor is about 2 × 10(-6) mol L (-1) and the response time is shorter than 6 s....
متن کاملβ-N-Oxalyl-l-α,β-diaminopropionic Acid (β-ODAP) Content in Lathyrus sativus: The Integration of Nitrogen and Sulfur Metabolism through β-Cyanoalanine Synthase
Grass pea (Lathyrus sativus L.) is an important legume crop grown mainly in South Asia and Sub-Saharan Africa. This underutilized legume can withstand harsh environmental conditions including drought and flooding. During drought-induced famines, this protein-rich legume serves as a food source for poor farmers when other crops fail under harsh environmental conditions; however, its use is limit...
متن کاملAction of the neurotoxin -N-oxalyl-L- , -diaminopropionic acid on glutamate metabolism of brain mitochondria.
Mammalian neurolathyrism is a progressive and degenerative disease of central nervous system originating from excessive consumption of Lafhyrus seeds, particularly those of L. sativus. Rao et al. [I] have isolated P-N-oxalyl-L-a&diaminopropionic acid (ODAP) from the seeds of L. satiuus and shown this substance to be the neurotoxin [ 1, 21 Characterization of the biochemical effect and cellular ...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1969
ISSN: 0306-3283
DOI: 10.1042/bj1120029